Deep Brain Stimulation (DBS) to Manage Thalamic Pain Syndrome (TPS)

What is the purpose of this study?

The purpose of this study is to learn about an experimental treatment for patients suffering from a severe pain syndrome known as thalamic pain syndrome (central pain syndrome) that has not responded to available treatment.

Can I participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:Thalamic Pain Syndrome, TPS, DBS, Deep Brain Stimulation, chronic pain, stroke
• Age: Between 21 - 70 Years
• Gender: Male or Female
• Inclusion Criteria:

  If you answer YES to all of these questions, you may be eligible to participate in this study:
  
      1. Do you have thalamic pain syndrome?
      2. Have antidepressants, anti-seizure medications, or oral narcotics failed to relieve your pain?
      3. Are you at least 21 years old?
  
          *A research team member will discuss all the criteria with you.
• Exclusion Criteria:

  If you answer YES to any of these questions, you may not be able to participate in this study:
  
      1. Do you have uncontrolled hypertension?
      2. Do you have a major neurological disorder other than thalamic pain syndrome?
      3. Have you had ablative intracranial surgery for thalamic pain syndrome?
      4. Do you have uncontrolled/severe personality or obsessive compulsive disorders?
  
          *A research team member will discuss all the criteria with you.

Detail Study Description

In this study, you will undergo brain surgery where a Deep Brain Stimulator (DBS) will be implanted into an area of your brain called the ventral capsular/ventral striatal area. Implanting the DBS includes inserting thin wires into your brain and a pacemaker on one side of your chest, just under the collarbone. The pacemaker will send electrical impulses to the lead which will stimulate the brain.

You will also be asked to perform tests of hand functioning and complete multiple study questionnaires regarding your mood, your pain, and the effects of your pain on your quality of life.

Study Treatments