If you take Levodopa to treat your Parkinson's disease, do you find that sometimes it does not work?

What is the purpose of this study?

This research is being done to find out if SYN115, a research study medication, can help the effectiveness of your Parkinson's Disease medications.

Can I participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:Parkinson's Disease, PD, moderate, severe, late, SYN115, L-dopa, Levodopa-carbidopa, wearing off, off period
• Age: Between 30 - 80 Years
• Gender: Male or Female
• Inclusion Criteria:

  If you answer YES to the following questions you may be eligible to participate in this study:
  
      1. Do you have Parkinson's Disease?
      2. Are you taking anti-parkinson disease medications?
      3. Has levodopa helped you?
  
          *A member of the study team will review all criteria with you
  
• Exclusion Criteria:

  If you answer YES to any of the following questions, you may not be eligible to participate in this study:
  
      1. Have you had neurosurgical intervention for Parkinson's disease?
      2. Are you using any medications with apomorphine, anti-psychotic or memory improving drugs?
      3. Do you have any uncontrolled or untreated current episode of major depression?
  
          *A member of the study team will review all criteria with you
  

Detail Study Description

The purpose of this study is to test the effects of SYN115 compared to placebo (a lookalike pill containing no medicine) on movement during periods when your Parkinson's Disease medication is or is not working. The study medication also is being tested on other symptoms that someone with Parkinson's Disease may experience (fatigue; loss of pleasure from activities making you happy; trouble thinking clearly and remembering things; less satisfying quality of life). The study also will look at any potential side effects from SYN115.

Study Treatments

SYN115